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Bcl-rambo Antibody (S-18) is a goat polyclonal IgG / Антитела поликлональные козьи IgG к Bcl-rambo (S-18)

• Bcl-rambo Antibody (S-18) is a goat polyclonal IgG provided at 200 µg/ml
• epitope mapping within an internal region of Bcl-rambo of human origin
• recommended for detection of Bcl-rambo of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine, porcine and avian
• blocking peptide, sc-54573 P

Apoptosis is defined as a set of cascades which, when initiated, program the cell to undergo lethal changes such as membrane blebbing, mitochondrial breakdown and DNA fragmentation. The Bcl-2 family of proteins plays a central regulatory role in apoptosis. Bcl-rambo, a member of the Bcl-2 family, localizes to the mitochondria and, like other Bcl-2 family members, contains all four BH domains. Although Bcl-rambo shares structural similarity to other Bcl-2 members, it differs from them in its unique C-terminal region. Bcl-rambo has a 250 amino acid sequence containing two tandem repeats that preceeds the membrane anchor region at its C-terminus. Additionally, it is the membrane anchor C-terminal region of Bcl-rambo, not its Bcl-2 homology motifs, that is responsible for its pro-apoptotic activity. Bcl-rambo induces apoptosis when overexpressed and appears to do so by promoting mitochondrial cyto-chrome c release. It may also facilitate the activation of caspase-3.

Информация для заказа:

Область использования: Первичные антитела и конъюгаты	Производство:	Santa Cruz
	Метод:
	Объем:	200 мкг/мл
	Кат. номер:	sc-54573
Цена (с НДС 20%):		В корзину
Наименование: Bcl-rambo Antibody (S-18) is a goat polyclonal IgG / Антитела поликлональные козьи IgG к Bcl-rambo (S-18). Примечание: SQ Category: Primary Antibodies, Species: m, r, h, Host Origin: human, Applications: WB, IP, IF, ELISA, UNSPSC: 12352203, datasheet