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MGMT Antibody (F-5) is a mouse monoclonal IgG2a

• MGMT Antibody (F-5) is a mouse monoclonal IgG_2a provided at 200 µg/ml
• raised against amino acids 1-207 representing full length MGMT of human origin
• recommended for detection of MGMT of human origin by WB, IP, IF, IHC(P) and ELISA

MGMT (O6-methylguanine-DNA methyltransferase) is transcriptionally activated in response to DNA damage and functions to repair mutagenic and cytotoxic O6-alkylguanine lesions caused by carcinogens or cytostatic drugs. MGMT induction by ionising radiation does not occur in p53-deficient mice, suggesting that MGMT induction may require p53. Similarly, MGMT mRNA and protein were shown to be inducible by ionising radiation, only in cell lines that express functional p53, and not in cell lines that do not express wild type p53. In contrast, high MGMT activity was associated with the presence of mutant p53, in a study of oral cancer cell lines. Similarly, MGMT activity was significantly lower in ovarian tumors with wildtype p53 than in tumors with mutant p53, supporting the view that wildtype p53 down-regulates the basal MGMT promoter.

Информация для заказа:

Область использования: Первичные антитела и конъюгаты	Производство:	Santa Cruz
	Метод:
	Объем:	200 мкг/мл
	Кат. номер:	sc-271155
Цена (с НДС 20%):		В корзину
Наименование: MGMT Antibody (F-5) is a mouse monoclonal IgG2a. Примечание: SQ Category: Primary Antibodies, Species: human, Host Origin: human, Applications: WB, IP, IF, IHC(P), ELISA, UNSPSC: 12352203, datasheet