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p73α Antibody (SPM431) is a mouse monoclonal IgG1 / Антитела моноклональные мышиные IgG1 к p73α (SPM431)

• p73α Antibody (SPM431) is a mouse monoclonal IgG₁ provided at 50µg/0.5 ml
• raised against amino acids 380-637 of p73α of monkey origin
• recommended for detection of p73 α of human and monkey origin by WB, IP and IF; non cross-reactive with p53 or p53-related p51/Ket protein; not recommended for detection of p73&beta
• See 1 citations for p73α Antibody (SPM431)

The p53 gene is a widely studied anti-oncogene, or tumor suppressor gene. The p53 gene product can act as a negative regulator of cell growth in response to DNA damage. Mutations and allelic loss of the p53 gene have been associated with malignant transformation in a wide variety of human tumors. p53 shares considerable sequence similarity with p73, a gene that maps to a region in chromosome 1 that is frequently deleted in neuroblastomas. However, p73 does not appear to be activated by DNA damaging agents. The p73 isoform p73å inhibits drug-induced apoptosis in small cell lung carcinoma cells, while the p73 isoform p73∫ promotes it. p73å also prevents Bax activation, mitochondrial dysfunction and caspase activation, and is able to reduce apoptosis induced by the BH3-only protein PUMA (p53 upregulated modulator of apoptosis). There is an equilibrium between p73å and p73∫, demonstrated by the fact that p73å inhibits the pro-apoptotic effect of p73∫.

Информация для заказа:

Область использования: Первичные антитела и конъюгаты	Производство:	Santa Cruz
	Метод:
	Объем:	50 µg/0.5 ml
	Кат. номер:	sc-56194
Цена (с НДС 20%):		В корзину
Наименование: p73α Antibody (SPM431) is a mouse monoclonal IgG1 / Антитела моноклональные мышиные IgG1 к p73α (SPM431) . Примечание: SQ Category: Primary Antibodies, Species: human and monkey, Host Origin: monkey, Applications: WB, IP, IF, UNSPSC: 12352203, datasheet