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Cytochalasin D / Цитохалазин Д

Cytochalasin D is used in actin polymerization studies and cytological research. Cytochalasins are fungal toxins characterized by a highly substituted hydrogenated isoindole ring to which is fused a macrocyclic ring. They are believed to bind to the barbed end of actin filaments resulting in inhibition of both the association and dissociation of subunits. Cytochalasin D is about 10-fold more effective than cytochalasin B (sc-3519) and does not inhibit monosaccharide transport across cell membranes. Treatment of cells with cytochalasin D results in rapid tyrosine phosphorylation of fish (SH3PXD2A), along with activation of Src. Cytochalasin D has been shown to increase intracellular Ca2+ levels and to activate p53-dependent pathways, causing arrest of the cell cycle. It may also act as an inhibitor of DNA synthesis, thyroid secretion, and growth hormone release.
Other Cytochalasins available: Cytochalasin A (sc-204705); Cytochalasin C (sc-202118); Cytochalasin E, Aspergillus clavatus (sc-202561); Cytochalasin H (sc-202119); Cytochalasin J (sc-202120)

References

1. Selden, L.A., et al. 1980. Biochem. Biophys. Res. Commun. 95: 1854-1860. PMID: 6448056
2. Cooper, J.A., 1987. J. Cell Biol. 105: 1473-1478. PMID: 3312229
3. Lock, P., et al. 1998. EMBO J. 17: 4346-4357. PMID: 9687503
4. Nair, U.B., et al. 2008. J. Mol. Biol. 384: 848-864. PMID: 18938176
5. Roy, S., et al. 2009. J Biomech. 42: 2562-2568. PMID: 19647827
6. Małecki, J.M., et al. 2010. Melanoma Res. 20: 52-58. PMID: 20010439

Информация для заказа:

Область использования: Реагенты SantaCruz	Производство:	Santa Cruz
	Метод:
	Объем:	1 mg
	Кат. номер:	sc-201442
Цена (с НДС 20%):		В корзину
Наименование: Cytochalasin D / Цитохалазин Д. Примечание: