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HIF-1α (H1α 67) / HIF-1α Antibody (H1alpha 67) is a mouse monoclonal IgG2b
- HIF-1α Antibody (H1alpha 67) is a mouse monoclonal IgG2b provided at 200 µg/ml
- raised against amino acids 432-528 of HIF-1α of human origin
- recommended for detection of HIF-1α of mouse, rat and human origin by WB, IP, IF and IHC(P); also reactive with additional species, including porcine
- See 21 citations for HIF-1α Antibody (H1alpha 67)
Cell growth and viability is compromised by oxygen deprivation (hypoxia). Hypoxia-inducible factors, including HIF-1å, HIF-1∫ (also designated Arnt 1), EPAS-1 (also designated HIF-2å) and HIF-3å, induce glycolysis, erythropoiesis and angiogenesis in order to restore oxygen homeostasis. Hypoxia-inducible factors are members of the Per-Arnt-Sim (PAS) domain transcription factor family. In response to hypoxia, HIF-1å is upregulated and forms a heterodimer with Arnt 1 to form the HIF-1 complex. The HIF-1 complex recognizes and binds to the hypoxia responsive element (HRE) of hypoxia-inducible genes, thereby activating transcription. Hypoxia-inducible expression of some genes such as Glut-1, p53, p21 or Bcl-2, is HIF-1å dependent, whereas expression of others, such as p27, GADD 153 or HO-1, is HIF-1å independent. EPAS-1 and HIF-3å have also been shown to form heterodimeric complexes with Arnt 1 in response to hypoxia. Информация для заказа:Область использования: | Производство: | Santa Cruz | Метод: | | Объем: | 200 мкг/мл | Кат. номер: | sc-53546 | Цена (с НДС 20%): | | В корзину | Наименование: HIF-1α (H1α 67) / HIF-1α Antibody (H1alpha 67) is a mouse monoclonal IgG2b. Примечание: SQ Category: Primary Antibodies, Species: m, r, h, Host Origin: human, Applications: WB, IP, IF, IHC(P), UNSPSC: 12352203, datasheet |
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