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/ Каталог / Реагенты для научных исследований / Антитела / Нейробиология
GAD-67 Antibody (K-87) is a mouse monoclonal IgG1 / Антитела мышиные моноклональные IgG1 к GAD-67 (K-87)
- GAD-67 Antibody (K-87) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against amino acids 87-106 of GAD-67 of human origin
- recommended for detection of GAD-67 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See 2 citations for GAD-67 Antibody (K-87)
There are two forms of glutamic acid decarboxylases (GADs) that are found in the brain: GAD-65 (also known as GAD2) and GAD-67 (also known as GAD1, GAD or SCP). GAD-65 and GAD-67 are members of the group II decarboxylase family of proteins and are responsible for catalyzing the rate limiting step in the production of GABA (g-aminobutyric acid) from L-glutamic acid. Although both GADs are found in the brain, GAD-65 localizes to synaptic vesicle membranes in nerve terminals, while GAD-67 is distributed throughout the cell. GAD-67 is responsible for the basal levels of GABA synthesis. In the case of a heightened demand for GABA in neurotransmission, GAD-65 will transiently activate to assist in GABA production. The loss of GAD-65 is detrimental and can impair GABA neurotransmission, however the loss of GAD-67 is lethal. Due to alternative splicing, two isoforms exist for GAD-67, the predominant GAD-67 form and the minor GAD-25 form. GAD-25 is not expressed in brain but can be found in a variety of endocrine tissues. Информация для заказа:| Область использования: | Производство: | Santa Cruz | | Метод: | | | Объем: | 100 µg/ml | | Кат. номер: | sc-58531 | | Цена (с НДС 20%): | | В корзину  |  Наименование: GAD-67 Antibody (K-87) is a mouse monoclonal IgG1 / Антитела мышиные моноклональные IgG1 к GAD-67 (K-87).
Примечание: SQ Category: Primary Antibodies,
Species: m, r, h,
Host Origin: ,
Applications: WB, IP, IF, IHC(P),
UNSPSC: 12352203,
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