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/ Каталог / Реагенты для научных исследований / Антитела / Антитела к мембранным рецепторам
Neu Antibody (9G6) is a mouse monoclonal IgG1 / Антитела мышиные моноклональные к Neu (9G6)
- Neu Antibody (9G6) is a mouse monoclonal IgG1 provided at 100 µg/ml
- epitope mapping within an extracellular domain of Neu of human origin
- recommended for detection of Neu gp185 of human origin by IP, IF, IHC(P) and FCM
- partial inhibition of protein tyrosine kinase activit
The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3), and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. Neu, a glycoprotein, undergoes transactivation upon hetero-dimerization with other EGF receptor family members. Neu heterodimerization with ErbB-3 recruits heregulin, which induces phosphoinositide (PI) 3-kinase activation. Activation of Neu potentiates tumor cell motility and protease secretion and invasion, and also modulates cell cycle checkpoint function, DNA repair and apoptotic responses. Amplification and/or overexpression of Neu occurs in 20-30% of breast carcinomas. Measurement of increased Neu expression can be a predictor of disease prognosis. Neu may also prove to be a promising target for therapeutic agents. Информация для заказа:| Область использования: | Производство: | Santa Cruz | | Метод: | | | Объем: | 100 мкг/мл | | Кат. номер: | sc-08 | | Цена (с НДС 20%): | | В корзину  |  Наименование: Neu Antibody (9G6) is a mouse monoclonal IgG1 / Антитела мышиные моноклональные к Neu (9G6).
Примечание: SQ Category: Primary Antibodies,
Species: human,
Host Origin: human,
Applications: IP, IF, IHC(P), FCM,
UNSPSC: 12352203,
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