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caspase-3 (L-18) / Козьи поликлональные антитела к каспазе 3 (L-18)

• goat polyclonal IgG, 200 µg/ml
• epitope mapping at the C-terminus of caspase-3 p20 of human origin
• recommended for detection of caspase-3 p20 and p17 subunits and full-length procaspase-3 of mouse, rat and human origin by WB, IP, IF and ELISA; partially cross-reactive with caspase-7; also reactive with additional species, including equine, canine, bovine, porcine and feline
• blocking peptide, sc-1225 P

Caspase-3, also known as apopain, SCA-1, Yama and CPP32, is an aspartate-specific cysteine protease that belongs to the ICE subfamily of caspases. Caspase-3 is expressed in cells as an inactive precursor from which the p17 and p11 subunits of the mature caspase-3 are proteolytically generated during apoptosis. The caspase-3 precursor is first cleaved at Asp175-Ser176 to produce the p11 subunit and the p20 peptide. Subsequently, the p20 peptide is cleaved at Asp28-Ser29 to generate the mature p17 subunit. The active caspase-3 enzyme is a heterodimer composed of two p17 and two p11 subunits. At the onset of apoptosis, caspase-3 proteolytically cleaves PARP at an Asp216-Gly217 bond. During the execution of the apoptotic cascade, activated caspase-3 releases SREBP from the membrane of the ER in a proteolytic reaction that is distinct from their normal sterol-dependent activation. Caspase-3 cleaves and activates SREBPs between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Caspase-3 also cleaves and activates caspase-6, -7 and -9. The human caspase-3 gene encodes a cytoplasmic protein that is highly expressed in lung, spleen, heart, liver, kidney and cells of the immune system.

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Область использования: Антитела к суппрессорам опухолей/ апоптическим белкам для вестерн-блоттинга Антитела к суппрессорам опухолей/ апоптическим белкам для иммунопреципитации Антитела к суппрессорам опухолей/ апоптическим белкам для иммунофлуоресценции Антитела к супрессорам опухолей/ апоптоз Первичные антитела и конъюгаты	Производство:	Santa Cruz
	Метод:
	Объем:	200 мкг/мл
	Кат. номер:	sc-1225
Цена (с НДС 20%):		В корзину
Наименование: caspase-3 (L-18) / Козьи поликлональные антитела к каспазе 3 (L-18). Примечание: SQ Category: Primary Antibodies, Species: m, r, h, Host Origin: human, Applications: WB, IP, IF, ELISA, UNSPSC: 12352203, datasheet