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/ Каталог / Реагенты для научных исследований / Антитела / Антитела к регуляторам транскрипции
TRF1 Antibody (H-242) is a rabbit polyclonal IgG / Антитела поликлональные кроличьи TRF1 (H-242),
- TRF1 Antibody (H-242) is a rabbit polyclonal IgG provided at 200 µg/ml
- epitope corresponding to amino acids 155-396 mapping within an internal region of TRF1 of human origin
- recommended for detection of TRF1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine
- See 3 citations for TRF1 Antibody (H-242)
Telomeric repeat binding factor 1 (TERF1, PIN2, TRF1, TRBF1) and 2 (TERF2, TRF2, TRBF2) are present at telomeres throughout the cell cycle where they regulate telomerase by acting in cis to limit the elongation of individual chromosome ends. Telomerase adds hexameric repeats of 5'-TTAGGG-3' to the ends of chromosomal DNA. This telomerase enzyme plays an influential role in cellular immortalization and cellular senescence. TRF1 negatively regulates telomere elongation, while TRF2 protects the chromosome ends by inhibiting end-to-end fusions. Down-regulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression. TRF1 has an acidic N-terminus while TRF2 has a basic N-terminus. TRF2 localizes in the nucleolus at G0 and S and diffuses out of the nucleolus in G2 phase. During mitosis TRF2 disperses from the condensed chromosomes and returns to the nucleolus at cytokinesis. Информация для заказа:| Область использования: | Производство: | Santa Cruz | | Метод: | | | Объем: | 200 мкг/мл | | Кат. номер: | sc-5596 | | Цена (с НДС 20%): | | В корзину  |  Наименование: TRF1 Antibody (H-242) is a rabbit polyclonal IgG / Антитела поликлональные кроличьи TRF1 (H-242),.
Примечание: SQ Category: Primary Antibodies,
Species: m, r, h,
Host Origin: human,
Applications: WB, IP, IF, ELISA,
UNSPSC: 12352203,
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