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Bcl-2 Antibody (C-2) is a mouse monoclonal IgG1

• Bcl-2 Antibody (C-2) is a mouse monoclonal IgG₁ provided at 200 µg/ml
• raised against amino acids 1-205 of human Bcl-2
• recommended for detection of Bcl-2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM
• agarose conjugate for IP studies, sc-7382 AC, 500 µg/0.25 ml agarose
• HRP conjugate, sc-7382 HRP, 200 µg/ml
• fluorescein (sc-7382 FITC) and rhodamine (sc-7382 TRITC) conjugates for immunofluorescence, 200 µg/ml
• phycoerythrin (sc-7382 PE), PerCP (sc-7382 PerCP) and PerCP-Cy5.5 (sc-7382 PCPC5) conjugates for intracellular FCM, 100 tests
• Alexa Fluor® 405 (sc-7382 AF405), Alexa Fluor® 488 (sc-7382 AF488) and Alexa Fluor® 647 (sc-7382 AF647) conjugates for FCM or immunofluorescence; 100 µg/2 ml
• See 382 citations for Bcl-2 Antibody (C-2)

Apoptosis is defined as a set of cascades which, when initiated, programs the cell to undergo lethal changes such as membrane blebbing, mitochondrial break down and DNA fragmentation. Bcl-2 is one among many key regulators of apoptosis, which are essential for proper development, tissue homeostasis, and protection against foreign pathogens. Human Bcl-2 is an anti-apoptotic, membrane-associated oncoprotein that can promote cell survival through protein-protein interactions with other Bcl-2 related family members, such as the death suppressors Bcl-xl, Mcl-1, Bcl-w, and A1 or the death agonists Bax, Bak, Bik, Bad, and Bid. The anti-apoptotic function of Bcl-2 can also be regulated through proteolytic processing and phospho-rylation. Bcl-2 may promote cell survival by interfering with the activation of the cytochrome c/Apaf-1 pathway through stabilization of the mitochondrial membrane. Mutations in the Bcl-2 gene can contribute to cancers where normal physiological cell death mechanisms are compromised by deregulation of the anti-apoptotic influence of Bcl-2.

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Область использования: Антитела к суппрессорам опухолей / апоптическим белкам для проточной цитометрии Антитела к суппрессорам опухолей/ апоптическим белкам для вестерн-блоттинга Антитела к суппрессорам опухолей/ апоптическим белкам для иммунопреципитации Антитела к суппрессорам опухолей/ апоптическим белкам для иммунофлуоресценции Антитела к супрессорам опухолей/ апоптоз Первичные антитела и конъюгаты	Производство:	Santa Cruz
	Метод:
	Объем:	200 мкг/мл
	Кат. номер:	sc-7382
Цена (с НДС 20%):		В корзину
Наименование: Bcl-2 Antibody (C-2) is a mouse monoclonal IgG1. Примечание: SQ Category: Primary Antibodies, Species: m, r, h, Host Origin: human, Applications: WB, IP, IF, IHC(P), FCM, UNSPSC: 12352203, datasheet