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ZO-1 Antibody (H-300) is a rabbit polyclonal IgG / Антитела поликлональные кроличьи к пептиду ZO-1 (H-300)

• ZO-1 Antibody (H-300) is a rabbit polyclonal IgG provided at 200 µg/ml
• epitope corresponding to amino acids 1437-1736 mapping at the C-terminus of ZO-1 (Zona occludens-1) of human origin
• recommended for detection of ZO-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine

Tight junctions are complexes of proteins that create intercellular boundaries between the plasma membrane domains of epithelial and endothelial cells. Many of the tight junction-associated proteins are members of the membrane-associated guanylate kinase (MAGUK) family and include occludin, ZO-1, ZO-2 and ZO-3 These proteins are thought to have both structural and signaling roles, and are characteristically defined by three protein-protein interaction modules: the PDZ domain, the SH3 domain and the guanylate kinase (GuK) domain. ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue.

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Область использования: Антитела для исследований в области нейробиологии для вестерн-блоттинга Антитела для исследований в области нейробиологии для иммунопреципитации Антитела для исследований в области нейробиологии для иммунофлуоресценции Нейробиология Первичные антитела и конъюгаты	Производство:	Santa Cruz
	Метод:
	Объем:	200 мкг/мл
	Кат. номер:	sc-10804
Цена (с НДС 20%):		В корзину
Наименование: ZO-1 Antibody (H-300) is a rabbit polyclonal IgG / Антитела поликлональные кроличьи к пептиду ZO-1 (H-300). Примечание: SQ Category: Primary Antibodies, Species: m, r, h, Host Origin: human, Applications: WB, IP, IF, ELISA, UNSPSC: 12352203, datasheet