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CD45R (HIS24)

CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphotyrosine phosphatase, a vital component for efficient tyrosine phosphorylation induction by the TCR/CD3 complex. The tyrosine phosphatase activity of CD45R is contained within the conserved intracellular domain. Src and Syk family protein tyrosine kinases are utilized by the TCR/CD3 complex to initiate signaling cascades. Several members of these two families, including Lck, Fyn and ZAP-70, have been implicated as physiological substrates of CD45R.

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Область использования: Антитела к сигнальным лимфоцитам Антитела к сигнальным лимфоцитам для вестерн-блоттинга Антитела к сигнальным лимфоцитам для иммуногистохимии Антитела к сигнальным лимфоцитам для иммунофлуоресценции Антитела к сигнальным лимфоцитам для проточной цитометрии Первичные антитела и конъюгаты	Производство:	Santa Cruz
	Метод:
	Объем:	200 мкг/мл
	Кат. номер:	sc-19615
Цена (с НДС 20%):		В корзину
Наименование: CD45R (HIS24). Примечание: SQ Category: Primary Antibodies, Species: rat, Host Origin: , Applications: WB, IF, IHC(P), FCM, UNSPSC: 12352203, datasheet