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PUMAα (N-20) / Козьи поликлональные антитела к PUMA α (N-20)

• goat polyclonal IgG, 200 µg/ml
• epitope mapping near the N-terminus of PUMAα of human origin
• recommended for detection of PUMAα of mouse, rat and human origin by WB, IF and ELISA
• blocking peptide, sc-20534 P

PUMA (Bcl-2 binding component 3, JFY1, PUMA/JFY1) is a mitochondrial pro-apoptotic Bcl-2 homology domain (BH3)-only protein that induces rapid apoptosis through a Bax- and mitochondria-dependent pathway. The PUMA gene encodes four proteins originating from different splice variants of the same transcript: PUMAå, ∫, © and ∂. Both PUMAå and PUMA∫ contain a BH3 domain, while PUMA© and PUMA∂ lack this domain. The BH3 domain is essential for binding of PUMAå and PUMA∫ to Bcl-2 or Bcl-xL. PUMA is an initiator of ©-radiation apoptosis and glucocorticoid-induced apoptosis in lymphoid cells in vivo. Bcl-2 family members generally regulate apoptosis and transmit death signals to mitochondria. Members of this family include both pro- and anti-apoptotic proteins that share homologous sequences known as Bcl-2 homology domains (BH1-4). The BH3 proteins, BID, NOXA, PUMA, NBK, Bim and Bad, are all pro-apoptotic and share sequence homology within the amphipathic alpha-helical BH3 region.

Информация для заказа:

Область использования: Антитела к суппрессорам опухолей/ апоптическим белкам для вестерн-блоттинга Антитела к суппрессорам опухолей/ апоптическим белкам для иммунофлуоресценции Антитела к супрессорам опухолей/ апоптоз Первичные антитела и конъюгаты	Производство:	Santa Cruz
	Метод:
	Объем:	200 мкг/мл
	Кат. номер:	sc-20534
Цена (с НДС 20%):		В корзину
Наименование: PUMAα (N-20) / Козьи поликлональные антитела к PUMA α (N-20). Примечание: SQ Category: Primary Antibodies, Species: m, r, h, Host Origin: human, Applications: WB, IF, ELISA, UNSPSC: 12352203, datasheet