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Annexin V Antibody (R-20) is a goat polyclonal IgG

• Annexin V Antibody (R-20) is a goat polyclonal IgG provided at 200 µg/ml
• epitope mapping at the N-terminus of Annexin V of human origin
• recommended for detection of Annexin V of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including bovine and porcine
• blocking peptide, sc-1929 P
• See 5 citations for Annexin V Antibody (R-20)

The annexin family of calcium-binding proteins is composed of at least ten mammalian genes and is characterized by a conserved core domain, which binds phospholipids in a Ca2+-dependent manner, and a unique amino-term-inal region, which may confer binding specificity. Annexin family members have been implicated as regulators of such diverse processes as ion flux, endocytosis and exocytosis, and cellular adhesion. For example, the crystal structure of Annexin III has suggested a hydrophilic amino-terminus with possible Ca2+ channel activity. Similarly, Annexin V has ion channel properties. Annexin IV, also referred to as endonexin, functions to regulate Cl-flux by mediating calmodulin kinase II (CaMKII) activity and Annexin V has been shown to regulate PKC activity. Annexin V is ubiquitously expressed at high levels in tissues and cells grown in tissue culture, while Annexin VIII exhibits a more limited distribution. Where co-expressed in the same tissues, Annexin VIII is often expressed at a 100-fold lower level than Annexin V. However, Annexin VIII is preferentially expressed in acute promyelocytic leukemia (APL) cells, which may relate to its role in hematopoietic cell differentiation.

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Область использования: Антитела к сигнальным интермедиаторам Антитела к сигнальным интермедиаторам для вестерн-блоттинга Антитела к сигнальным интермедиаторам для иммунофлуоресценции Первичные антитела и конъюгаты	Производство:	Santa Cruz
	Метод:
	Объем:	200 мкг/мл
	Кат. номер:	sc-1929
Цена (с НДС 20%):		В корзину
Наименование: Annexin V Antibody (R-20) is a goat polyclonal IgG. Примечание: SQ Category: Primary Antibodies, Species: m, r, h, Host Origin: human, Applications: WB, IP, IF, ELISA, UNSPSC: 12352203, datasheet