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Fap-1 Antibody (H-300) is a rabbit polyclonal IgG
- Fap-1 Antibody (H-300) is a rabbit polyclonal IgG provided at 200 µg/ml
- epitope corresponding to amino acids 1-300 of Fap-1 of human origin
- recommended for detection of Fap-1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- See 12 citations for Fap-1 Antibody (H-300)
In contrast to the growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally-related receptors containing a conserved “death domain” belonging to the TNF receptor superfamily. Putative downstream receptors of FAS include TRADD, FADD and RIP. A novel protein tyrosine phosphatase, Fap-1 (for FAS-associated phosphatase) (originally designated PTP-BAS), has been shown to associate with the carboxy terminus fifteen amino acids of FAS. Three isoforms of the protein result from alternative RNA splicings, the longest of which encodes a protein 2485 amino acids in length. Although lacking a transmembrane region, Fap-1 does contain a membrane-binding domain, similar to that found in cytoskeleton-associated proteins such as ezrin. Fap-1 does not seem to associate with CD40 or death domain proteins such as TNF-RI and TNF-RII. Информация для заказа:| Область использования: | Производство: | Santa Cruz | | Метод: | | | Объем: | 200 мкг/мл | | Кат. номер: | sc-15356 | | Цена (с НДС 20%): | | В корзину  |  Наименование: Fap-1 Antibody (H-300) is a rabbit polyclonal IgG.
Примечание: SQ Category: Primary Antibodies,
Species: m, r, h,
Host Origin: human,
Applications: WB, IP, IF, IHC(P), ELISA,
UNSPSC: 12352203,
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