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ADAMTS-4 Antibody (H-74) is a rabbit polyclonal IgG
- ADAMTS-4 Antibody (H-74) is a rabbit polyclonal IgG provided at 200 µg/ml
- epitope corresponding to amino acids 764-837 mapping at the C-terminus of ADAMTS-4 of human origin
- recommended for detection of ADAMTS-4 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- See 1 citations for ADAMTS-4 Antibody (H-74)
ADAMTS (a disintegrin and metalloprotease with Thrombospondin motifs) protein family members contain an N-terminal propeptide domain, a metalloproteinase domain, a disintegrin-like domain, and a C-terminus that contains a varying number of thrombospondin type-1 (TSP-1) motifs. ADAMTS-4 (also known as aggrecanase-1) is an 837 amino acid, Zn-metalloprotease that mediates proteolytic degradation of Aggrecan, a major component of cartilage. Aggrecan swells and hydrates the collagen fibril meshwork in cartilage, which confers compressibility and resilience. Degradation of Aggrecan is a factor that contributes to erosion of articular cartilage in arthritic diseases. Traditional matrix metalloproteinases (MMPs) cleave Aggrecan at Asn 341-Phe 342 whereas ADAMTS-4 cleaves at Glu 373-Ala 374. Inhibitors tailored to both MMPs and ADAMTSs may hinder the rate of cartilage degradation in arthritic individuals. Информация для заказа:| Область использования: | Производство: | Santa Cruz | | Метод: | Western Blot | | Объем: | 200 мкг/мл | | Кат. номер: | sc-25582 | | Цена (с НДС 20%): | | В корзину  |  Наименование: ADAMTS-4 Antibody (H-74) is a rabbit polyclonal IgG .
Примечание: SQ Category: Primary Antibodies,
Species: m, r, h,
Host Origin: human,
Applications: WB, IP, IF, ELISA,
UNSPSC: 12352203,
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